One-Pot Synthesis of Thiazoles via Hantzsch Thiazole Reaction and Their Antimicrobial Activity
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چکیده
منابع مشابه
Nanocrystalline TiO2 as an efficient and reusable catalyst for the one-pot synthesis of polyhydroquinolien derivatives via Hantzsch reaction
An efficient synthesis of polyhydroquinoline derivatives was reported via four-component coupling reactions of aldehydes, 1,3-dicarbonyl ketones (dimedone or 1,3-cyclohexanedione), ethyl acetoacetate or methyl acetoacetate and ammonium acetate in the presence of a catalytic amount of nanocrystalline TiO2 under solvent free conditions. The reported method is mild, rapid and has the advantages su...
متن کاملNanocrystalline TiO2 as an efficient and reusable catalyst for the one-pot synthesis of polyhydroquinolien derivatives via Hantzsch reaction
An efficient synthesis of polyhydroquinoline derivatives was reported via four-component coupling reactions of aldehydes, 1,3-dicarbonyl ketones (dimedone or 1,3-cyclohexanedione), ethyl acetoacetate or methyl acetoacetate and ammonium acetate in the presence of a catalytic amount of nanocrystalline TiO2 under solvent free conditions. The reported method is mild, rapid and has the advantages su...
متن کاملOne-pot Synthesis and Characterization of Highly Functionalized Thiazoles
A facile and efficient one-pot three-step process for the synthesis of 5-acetyl-2-imino-4-methylthiazoles via the cyclocondensation of 3-thiocyanatoacetylacetone with various hydrazine or hydrazide derivatives in EtOH has been developed. 3-Thiocyanatoacetylacetone itself has been synthesized as the intermediate from substitution reaction of thiocyanate with 3-chloroacetylacetone. B...
متن کاملOne –Pot Synthesis of Polyhydroquinoline Derivatives via Hantzsch Condensation Reaction Using Nanosized Magnesium Oxide as Heterogeneous Catalyst
An efficient, recyclable and environmental-friendly synthetic route to polyhdroquinoline derivatives have been developed via multi-component one-pot Hantzsch reaction of various aromatic aldehyde, 2 equivalents of 5,5-dimethyl-1,3-cyclohexanedione (dimedone), ethyl acetoacetate and ammonium acetate using nano magnesium oxide as a catalyst in ethanol under reflux condition. Reaction with 4-chlor...
متن کاملA facile one-pot synthesis of thiazoles and thiazolyl-pyrazole derivatives via multicomponent approach
Thiazoles and thiazolyl-pyrazole derivatives have been efficiently synthesized under neat reaction conditions in excellent yields. Condensation of 3-(2-bromoacetyl)-4-hydroxy-6-methyl-2H-pyran-2-one (1), thiosemicarbazide (2) and various carbonyl compounds (3 & 5) gave corresponding thiazole (4) and thiazolylpyrazole derivatives (6) in excellent yields by using Hantzsch-Thiazole synthesis. The ...
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ژورنال
عنوان ژورنال: Asian Journal of Chemistry
سال: 2016
ISSN: 0970-7077,0975-427X
DOI: 10.14233/ajchem.2016.19603